Depression Research Today is a free monthly online journal that collates and summarizes the latest research about Depression, including details on clinical depression, medication, symptoms, treatment, counselling, therapy.

Combined treatments for major depression.

Joffe RT

New Jersey Medical School, Department of Psychiatry, Maplewood, NJ 07040, USA. Rjoffe51@verizon.net

Major depression is a chronic disorder with a high morbidity and mortality. Approved treatment for major depression at present includes monotherapy with antidepressants of different pharmacologic classes. There is increasingly widespread use of two other options: augmentation, the addition to an antidepressant of a second compound that is not an antidepressant when used alone; and combination, which is the use of two antidepressants concurrently to enhance or accelerate response. This review focuses on the data available to support these various augmentation and combination treatments.

Published 23 August 2007 in Expert Opin Investig Drugs, 16(9): 1379-89.
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